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Pterostiblene Assists With the Lowering of Blood Pressure

By Rob Poulos...

Blood pressure in adults may be reduced with the help of a form of pterostilbene. Pterostilbene is a compound that naturally occurs in blueberries. A clinical trial was done on the effects of this compound and the findings were presented at the American Heart Association’s 2012 Scientific Sessions on High Blood Pressure Research on September 20,2012 in Washington, D.C.

This study was a double-blind, placebo-controlled, randomized study undertaken by the University of Mississippi School of Medicine and School of Pharmacy researchers. The researchers were looking to see if pterostilbene improves cardiovascular health. This ingredient is being marketed under the name pTeroPure.

Researchers studied 80 patients suffering from high cholesterol. High cholesterol was defined as a total cholesterol level of 200 or greater and or an LDL cholesterol level of 100 or greater. For six to eight weeks, twice a day, study participants took 125 mg doses of this compound, 50mg doses, 50mg doses combined with 100 mg of grape extract or a placebo, according to the principal investigator of the study, Daniel M. Riche. Body weight, blood pressure and blood lipids were assessed at both the beginning and end of the study for each participant.

Reduced systolic and diastolic blood pressure were seen in those patients receiving the high pterostilbene. Patients who received the low dose of pterostilbene combined with grape extract showed a decrease in systolic blood pressure, according to Mr. Riche. Mr. Riche works at the UM Medical Center in Jackson as an assistant professor of pharmacy practice and medicine.

Significant reductions in blood pressure were seen in those in the high-dose pterostilbene group as compared to those who received a placebo. This reduction was 7.8 mmHg in systolic BP and 7.3 mmHg in diastolic BP. LDL cholesterol increased in those taking pterostilbene, but this increase was less in those already on medication to lower cholesterol. Those who received the grape extract didn’t see any reduction. Those not on cholesterol-lowering medication also saw a decrease in body weight when taking pterostilbene. This was not seen in those taking other doses or the placebo.

ChromaDex patented the use of this ingredient from UM for commercial development in 2010. They are marketing it under the brand name pTeroPure in their BluScience line of dietary supplements. This line is available through 17,000 outlets across American. The company provided the university with support during the year long study. Frank Jaksch Jr., the CED and co-founder of ChromaDex states, they are pleased that the university undertook the first human study to provide clinical proof of this ingredient. The study adds credibility to the products while allowing for further market expansion opportunities.

Co-investigators in this study included Dr. Marion Woodford, professor of medicine, Michael E. Griswold, director of UMMC’s Center for Biostatistics, Justin M. Cherman, associate professor of pharmacy practice and Krista D. Riche, a St. Dominic Hospital in Jackson clinical pharmacy specialist. David D. Allen, Dean of the School of Pharmacy, states the school is pleased to be working with ChromaDex to improve the health and well-being of Americans and people the world over though the use of this dietary supplement ingredient.

ChromaDex is an industry leader in terms of biochemical and phytochemical reference standards as well as the creation of intellectual property associated with this. They are committed to providing dietary supplement, nutraceutical, food, cosmetic and beverage industries with unique ingredients as well as analytical services and tools designed to meet all quality, efficacy, product regulatory, and safety standards along with sustainable ‘green chemistry’.

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